Photothermal therapy via a gold nanoparticle-coated stent for treating stent-induced granulation tissue formation in the rat esophagus

Abstract Minimally invasive therapies using stent technology are currently limited by stent-induced granulation tissue formation adjacent to the stent. The effectiveness of photothermal therapy (PTT) a gold nanoparticle (AuNP)-coated for treating in rat esophagus was investigated. All experiments were approved animal research committee our institution. An AuNP-coated, self-expandable metallic (SEMS) produced conduct PTT under near-infrared laser irradiation. Forty rats randomly divided into four groups (10 each). animals group A (non-coated SEMS) and B (AuNP-coated SEMS with local heating at 65 °C 4 weeks) sacrificed weeks after placement. C D 8 assessed histopathology. procedures successful all animals. Seven excluded because migration (n = 2) death 5). Granulation formation-related variables significantly higher than B–D (all p < 0.05). Heat-shock protein 70 (HSP70) TUNEL expression lower AuNP-coated successfully treated placement esophagus.